High-quality

Mesenchymal Stem Cell Exosomes

PEXT is secretomes separated from stem cell conditioned media by filtering cells and impurities. It is well known that it contains plenty of bio-active substances such as genetic materials, growth factors and cytokines secreted by differentiating stem cells.

Beyond the Source: The Objective Standard for Quality.

PEXT™ solves the fundamental challenge in regenerative medicine. For years, applications could confirm a cell's type and origin, but never its true quality or regenerative potential. This left clinical efficacy to chance.

Using advanced intracellular glutathione analysis powered by the Freshtracer™ system, we have created PEXT™, the world's first and only exosome with objectively proven quality. This breakthrough finally moves beyond identity to certify potency, empowering practitioners to achieve predictable and superior outcomes with confidence.

A New Era of Certainty in Cellular Regeneration.

The promise of regenerative medicine has always been limited by a critical uncertainty: the question of quality. While science could identify the cell, it couldn't measure its power. Until now.

PEXT™ represents a monumental leap forward. We've pioneered a method to analyze the very life force of parental cells—their intracellular glutathione levels—to select only the most potent for exosome production. The result is PEXT™, the only exosome in the world built upon an objective signature of quality. Forget the guesswork. The future of predictable, effective regenerative treatment is here.

What is Glutathione, and Why is it the Ultimate Biomarker for Cellular Quality?

Think of Glutathione (GSH) as the master guardian and CEO of the cell. It is a powerful antioxidant produced naturally within every cell in the body, and its presence in high, stable quantities is one of the most critical indicators of cellular health, resilience, and regenerative power.

Its importance can be understood through four vital functions:

1. The Elite Defense Against Stress: Every day, our cells are attacked by damaging free radicals, leading to oxidative stress—a primary driver of aging and cellular decline. Glutathione is the frontline defense, neutralizing these threats. A cell with high Glutathione levels is not just surviving; it's thriving, capable of withstanding stress and maintaining its structural and functional integrity.

2. The Fuel for Cellular Energy: Glutathione is essential for the optimal function of the mitochondria, the cell's "power plants." High levels of Glutathione ensure the cell has the energy it needs to perform vital tasks like repair, signaling, and replication. This cellular energy is directly transferred to the exosomes it produces.

3. The Master Detoxifier: Glutathione binds to toxins, pollutants, and metabolic waste, safely escorting them out of the cell. A cell with an efficient detoxification system is cleaner, more efficient, and operates at peak performance, producing pure and effective exosomes.

4. The Conductor of Regeneration: Most importantly for regenerative applications, a cell's Glutathione status directly correlates with its ability to send clear, powerful signals for tissue repair and renewal. A cell rich in Glutathione is a potent communication hub, producing exosomes packed with the high-quality proteins and genetic information needed to orchestrate healing.

Beyond Quantity: Why Glutathione Heterogeneity is Crucial

True cellular quality isn't just about how much Glutathione a cell has; it's about how evenly it's distributed. This is Glutathione Heterogeneity.

Imagine a city's defense force (Glutathione) all clumped in one district while the rest of the city is left vulnerable. Even with a large force, the city is weak. Similarly, a cell with high heterogeneity—uneven patches of low Glutathione—is internally stressed and dysfunctional. This indicates a cell that is struggling to maintain balance, making it a poor candidate for producing effective exosomes.

The PEXT Advantage: A Commitment to True Quality

The Freshtracer™ system allows us to go beyond simple averages. We perform a detailed analysis of both the intracellular Glutathione levels and its homogeneity within each parental stem cell.

By selecting only those cells that demonstrate high, evenly distributed Glutathione, we are choosing cells that are verifiably resilient, energetic, and primed for regeneration. This ensures that PEXT™ exosomes are derived from a source of objectively measured, superior quality. This is how we move from the uncertainty of potential to the certainty of proven potency.

Viral Contamination Test

We have confirmed that the conditioned media from human umbilical cord-derived stem cells do not contain the following virus, including the biological ingredient standard.

• HIV (AIDS)

• CMV (cytomegalovirus)

• HBV (Hepatitis B virus)

• HCV (Hepatitis C virus)

Identification of Stem Cell

Human umbilical cord-derived stem cells used to produce conditioned media confirm quality and safety by analyzing a distinctive group of surface markers. In addition, the supernatant obtained by culturing the cells contains sufficient cell-derived components required as cosmetics raw materials, and it is also confirmed that the cells are appropriate for producing the conditioned media

Safety of PEXT

We have confirmed the safety of the conditioned media from human umbilical cord-derived stem cells with various test

Particles in PEXT

We have analyzed the distribution and number of particles of PEXT with nanoparticle tracking analysis (NTA). PEXT from high-quality stem cell screened by FreSHtracer^TM has much more particles, which is mostly distributed between 30~150 nm.

Protein in PEXT

We have analyzed the protein profile of PEXT with proteome profiler and the followings are the protein present in a large amount in a solution.

•     CD14

Activation of Immune Response, Wound Healing

•     TfR (Transferrin Receptor)

Support of Cell Proliferation, Role in Immune Response,
Red Blood Cell Production, positive effects on skin

•     TSP-1 (Thrombospondin-1)

•      

Regulation of Immune Responses,
Promotion of Cell Adhesion and Migration,
Activation of TGF-β, positive effects on skin

•     FD (Complemet Factor D)

•      

Inflammatory Response Modulation,
Opsonization of Pathogens, Inhibition of lipolysis

•     PDGF-AA (Platelet-derived Growth Factor-AA)

Cell Proliferation and Survival,

Role in Wound Healing,
Angiogenesis, positive effects on skin and hair

Wound Healing Effect

Cell Function Modulation

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Anti-inflammatory Effect

Immune Modulation