HELIXERA

Experience next generation regenerative medicine

Our formulations are engineered for optimal purity, solubility, and efficacy—backed by world-class research.

 Our formulations are engineered for optimal purity, solubility, and efficacy—backed by world-class research.

Helixera combines the world’s first synergistic blend of PDRN (68 kDa) and PN (1,521 kDa) with powerful Glutathione, delivering unmatched skin rejuvenation and regeneration. Our precisely engineered formulation features optimal molecular sizes and <0.2% concentration for superior solubility, absorption, and sustained results. Developed in collaboration with leading university scientists, Helixera sets a new gold standard for purity, consistency, and advanced skin care innovation.

The Foundation of Cellular Regeneration: PDRN & PN

At the core of advanced skin rejuvenation lies the science of Polynucleotides (PN) and Polydeoxyribonucleotides (PDRN). These are powerful, naturally derived biopolymers—fragments of DNA that act as essential building blocks for cellular repair and regeneration. When introduced into the skin, they send precise signals to our cells, awakening their innate healing capabilities. PDRN and PN work at a fundamental level by stimulating fibroblast activity, which boosts the production of collagen and elastin, the primary components of firm, youthful skin. Furthermore, they create an optimal environment for tissue health by improving hydration, reducing inflammation, and enhancing the skin's own restorative processes. Helixera has harnessed the unique potential of these molecules by creating the world's first synergistic blend, combining two distinct molecular weights to deliver a comprehensive, multi-layered approach to true biological revitalization.

PDRN (Polydeoxyribonucleotide)

-Source: Derived from highly purified DNA extracted from the sperm of *Oncorhynchus mykiss* (Salmon Trout) or *Oncorhynchus keta* (Chum Sal

mon)[1][5][6].

-Composition: A mixture of deoxyribonucleotides with molecular weights ranging from 50 to 1,500 kDa, most commonly between 80 and 200 kDa[1][5].

- Safety: The manufacturing process ensures the absence of active proteins and peptides, minimizing the risk of immune reactions[1][5].

- Mechanism: PDRN activates adenosine A₂A receptors, promoting tissue repair, angiogenesis (formation of new blood vessels), and anti-inflammatory effects[1][2][7].

- Clinical Uses: Used for wound healing (e.g., diabetic foot ulcers), skin regeneration, scar reduction, and in aesthetic medicine to improve skin elasticity, hydration, and texture[1][6][7].

PN (Polynucleotides)

- Source: Also derived from salmon DNA, but more broadly refers to any chain of nucleotide units[3][4].

- Composition: Chains of nucleotides (with phosphate, sugar, and nitrogenous bases), structurally similar to human DNA[3].

- Mechanism: Polynucleotides interact with skin cells, particularly fibroblasts, to stimulate collagen and elastin production, provide hydration, and act as antioxidants[3].

- Clinical Uses: Primarily used in aesthetic medicine for skin rejuvenation, hydration, and protection against environmental damage[3][4].

PDRN and PN are both innovative DNA-derived treatments with overlapping but distinct benefits. PDRN is particularly noted for its wound healing and anti-inflammatory properties, while PN is favored for its high-concentration, direct skin rejuvenation and hydration effects.

Both are considered safe and effective for use in regenerative and aesthetic medicine, with applications tailored to individual patient needs

The Helixera Advantage: A New Standard in Skin Regeneration

The Helixera difference is born from an uncompromising commitment to scientific precision and efficacy. Our revolutionary formula, developed in collaboration with world-leading scientists at University, is engineered to deliver superior results. At its heart is a unique synergistic blend of two distinct polynucleotide forms: a fast-acting, low molecular weight PDRN (68 kDa) that rapidly penetrates to initiate cellular repair, and a high molecular weight PN (1,521 kDa) that creates a structural scaffold for sustained regeneration and deep hydration. This powerful dual-action is perfected by our ultra-low concentration (<0.2%), which ensures optimal solubility, maximizes bioavailability, and enhances safety. This meticulous engineering translates into tangible clinical benefits—accelerated healing, visibly improved skin elasticity, and profound, lasting rejuvenation that sets a new gold standard in advanced skincare.

HELIXERA PDRN (68 kDa) and PN (1,521 kDa) are scientifically positioned for complementary effects. While 132 kDa remains the gold standard for PDRN in wound healing, your lower mean weight may enhance solubility without sacrificing efficacy. For PN, your 1,521 kDa median aligns with emerging standards for long-chain polymers, making it ideal for sustained regeneration. Highlight these molecular differentiators alongside your <0.2% concentration to emphasize superior formulation science.

Certificate of Analysis

The Definitive Choice for True Regeneration

In a field of solutions that often deliver only temporary or superficial improvements, Helixera stands apart. While conventional treatments may offer a single benefit, our formula moves beyond these limitations. We engineered the world's first synergistic blend of PDRN and PN to provide a complete, dual-action regenerative response—delivering both rapid cellular repair and sustained structural rejuvenation. This isn't just another skin booster; it is a meticulously crafted biological tool, validated by elite university research and defined by its uncompromising purity and precision. When you choose Helixera, you are not simply selecting a product; you are investing in a new gold standard of care that delivers profound, consistent, and lasting results. Don't settle for partial solutions. Demand true regeneration.